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药理学

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陈雪彦博士-副教授

发布时间:2019-07-30   浏览次数:0

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陈雪彦,女,汉族,中共党员,博士,副教授,硕士生导师。2000年毕业于8883net新浦京游戏药学系。先后在8883net新浦京游戏获得药理学硕士(2003年)和博士学位(2009年),现于8883net新浦京游戏药理教研室任教。主要从事药物药理及毒理研究。研究方向主要是肺动脉高压、肺损伤等肺循环疾病以及右室重构机制的研究。任现职期间主持2项河北省自然科学基金项目,2项厅局级项目,参与国家自然科学基金、河北省自然科学基金以及河北省教育厅科技研究计划项目等课题5项,另主持及参与校级教学课题及大学生创新项目6项,参编著作3部;任现职以来以第一(含共同第一)或通讯作者发表SCI论文8篇,其中JCR1区以上SCI 论文2篇,获河北省科技进步二等奖一项(第三),河北省医学科技奖一项(第一)。

代表性论文

1.Xueyan Chen; Kerang Xie; Xiaofei Zhang; Xinshun Gu; Yi Wu; Suwen Su ; Bradykinin receptor participates in doxorubicin‐induced cardiotoxicity by modulating iNOS signal pathway, Journal of Biochemical and Molecular Toxicology, 2023, 37(8): e23393.

2. Huanlong Liu; Zhenhua Pan; Xindi Ma; Junru Cui; Juan Gao; Qingfeng Miao; Zhongning Zhu; Xueyan Chen; Suwen Su ; ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway, BMC Pharmacol Toxicol , 2022, 23(1): 24-38.

3. Zhang W, Chen XY, Su SW, Jia QZ, Ding T, Zhu ZN, Zhang T. Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysisof randomized clinical trials. Neurol Sci. 2016, 37(1): 57-65. 

4. Huan-long Liu, Xue-yan Chen, Jie-ru Li, Su-wen Su, Tao Ding, Chen-xia Shi, Yun-fa Jiang*, Zhong-ning Zhu,Efficacy and safety of PAH-specific therapy in pulmonary arterial hypertension: a meta-analysis of randomized clinical trials. Chest,2016,150(2): 353-366.

5. Xueyan Chen, Yu Zhang, Zhongning Zhu, Huanlong Liu, Huicai Guo, Chen Xiong, Kerang Xie, Xiaofei Zhang and Suwen Su. Protective effect of berberine on doxorubicin induced acute hepatorenal toxicity in rats. Mol Med Rep, 2016, 13(5): 3953-3960.

6.Chen X, Guo H, Li Q, Zhang Y, Liu H, Zhang X, Xie K, Zhu Z, Miao Q, Su S. Protective effect of berberine onaconite induced myocardial injury and the associatedmechanisms. Mol Med Rep. 2018, 18: 4468-4476. 

7.  Liu H, Chen X, Han Y, Li C, Chen P, Su S, Zhang Y, Pan Z. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomed Pharmacother. 2014, 68: 267-275.

8. Xueyan Chen, Huanlong Liu, Zhenhua Pan, Qingfeng Miao, Yongjian Zhang. The inhibitory effects of m-nisoldipine on the 5-hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells via Ca2+ antagonism and antioxidant mechanisms. European Journal of Pharmacology. 2012, 686: 32-40.